Domain

Histone acetyltransferase domain, MYST-type (IPR002717)

Short name: HAT_MYST-type

Domain relationships

None.

Description

Histone acetyltransferases (HATs) fall into at least four different families based on sequence conservation within the HAT domain [PMID: 18722564]. The MYST family is the largest family of HATs and is named after the founding members: MOZ, Ybf2/ Sas3, Sas2 and Tip60. MYST proteins mediate many biological functions including gene regulation, DNA repair, cell-cycle regulation and development [PMID: 21132344] and have been shown to acetylate several non-histone substrates [PMID: 19303850]. MYST proteins are autoregulated by posttranslational modifications [PMID: 22020126].

The MYST-type HAT domain contains three regions: a central region associated with acetyl-CoA cofactor binding and catalysis in addition to flanking N- and C-terminal regions harboring respectively a C2HC-type zinc finger and a helix- turn-helix DNA-binding motif. The N- and C-terminal segments directly flanking the catalytic core are likely to play an important role in histone substrate binding [PMID: 11106757, PMID: 17925393]. The catalytic mechanism for the MYST-type HAT domain is still unresolved but seems to involve a conserved glutamate that functions to abstract a proton from lysine to promote the nucleophilic attack on the acetyl carbonyl carbon of acetyl-CoA [PMID: 11106757, PMID: 22918831, PMID: 22020126, PMID: 18245364].

GO terms

Biological Process

GO:0016573 histone acetylation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0004402 histone acetyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam