Domain

PIN domain (IPR002716)

Short name: PIN_dom

Domain relationships

Description

PIN domains are small protein domains identified by the presence of three strictly conserved acidic residues. Apart from these three residues, there is poor sequence conservation [PMID: 21036780].

PIN domains are found in eukaryotes, eubacteria and archaea. In eukaryotes they are ribonucleases involved in nonsense mediated mRNA decay [PMID: 17053788] and in processing of 18S ribosomal RNA [PMID: 19706509]. In prokaryotes, they are the toxic components of toxin-antitoxin (TA) systems, their toxicity arising by virtue of their ribonuclease activity. The PIN domain TA systems are now called VapBC TAs(virulence associated proteins), where VapB is the inhibitor and VapC, the PIN-domain ribonuclease toxin [PMID: 21036780].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
Pfam
Pfam
SMART
Pfam