Dilute domain (IPR002710)
Short name: Dilute_dom
Overlapping homologous superfamilies
- Dilute domain (IPR002710)
- Afadin, cargo binding domain (IPR037977)
- Class XI myosin, cargo binding domain (IPR037975)
- Dilute domain-containing protein, fungi, CBD domain (IPR037986)
- Myosin 5a, cargo-binding domain (IPR037988)
- Myosin 5b, cargo-binding domain (IPR037990)
- Myosin 5c, cargo-binding domain (IPR037991)
- Rasip1/Radil, cargo-binding domain (IPR037983)
The myosin superfamily consists of at least 15 distinct classes of presumed actin-based molecular motors. All members of the superfamily share a similar motor domain and a tail portion which is diagnostic of the class [PMID: 11212352].
Class V myosins are actin-based molecular motors that function in relatively long-range movements of many intracellular cargoes including organelles, membrane vesicles, and mRNA [PMID: 10931864]. These motors are ubiquitously found in all eukaryotes. Class V myosins are characterised by the presence of a conserved globular domain at the C terminus of the tail portion: the dilute domain [PMID: 7667878]. Myosin V moves via attachment of its amino terminal head (motor) domain to actin cables; its carboxyl terminal dilute domain anchors it to cargoes via attachments to organelle-specific receptors [PMID: 10931864, PMID: 15684027].
The dilute domain is also found in the afadin family. Afadins are nectin and actin filament-binding proteins that connect nectin to the actin cytoskeleton [PMID: 12456712]. The dilute domain of afadin appears to be responsible for actin stress fibre formation [PMID: 25712270].