Dilute domain (IPR002710)

Short name: Dilute_dom

Overlapping homologous superfamilies


Domain relationships


The myosin superfamily consists of at least 15 distinct classes of presumed actin-based molecular motors. All members of the superfamily share a similar motor domain and a tail portion which is diagnostic of the class [PMID: 11212352].

Class V myosins are actin-based molecular motors that function in relatively long-range movements of many intracellular cargoes including organelles, membrane vesicles, and mRNA [PMID: 10931864]. These motors are ubiquitously found in all eukaryotes. Class V myosins are characterised by the presence of a conserved globular domain at the C terminus of the tail portion: the dilute domain [PMID: 7667878]. Myosin V moves via attachment of its amino terminal head (motor) domain to actin cables; its carboxyl terminal dilute domain anchors it to cargoes via attachments to organelle-specific receptors [PMID: 10931864, PMID: 15684027].

The dilute domain is also found in the afadin family. Afadins are nectin and actin filament-binding proteins that connect nectin to the actin cytoskeleton [PMID: 12456712]. The dilute domain of afadin appears to be responsible for actin stress fibre formation [PMID: 25712270].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles