Domain

DNA-repair protein Xrcc1, N-terminal (IPR002706)

Short name: Xrcc1_N

Domain relationships

Description

DNA-repair protein Xrcc1 functions in the repair of single-strand DNA breaks in mammalian cells and forms a repair complex with beta-Pol, ligase III and PARP [PMID: 10467087]. The NMR solution structure of the Xrcc1 N-terminal domain (Xrcc1 NTD) shows that the structural core is a beta-sandwich with beta-strands connected by loops, three helices and two short two-stranded beta-sheets at each connection side. The Xrcc1 NTD specifically binds single-strand break DNA (gapped and nicked) and a gapped DNA-beta-Pol complex [PMID: 10467102].

GO terms

Biological Process

GO:0000012 single strand break repair

Molecular Function

GO:0003684 damaged DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam