Family

5-formyltetrahydrofolate cyclo-ligase (IPR002698)

Short name: FTHF_cligase

Family relationships

None.

Description

5-formyltetrahydrofolate cyclo-ligase or methenyl-THF synthetase EC:6.3.3.2 catalyses the interchange of 5-formyltetrahydrofolate (5-FTHF) to 5-10-methenyltetrahydrofolate, this requires ATP and Mg2+ [PMID: 8522195]. 5-FTHF is used in chemotherapy where it is clinically known as Leucovorin [PMID: 8034591].

This entry also includes the 5-formyltetrahydrofolate cyclo-ligase-like protein COG0212 (At1g76730) from Arabidopsis. It does not possess the 5-formyltetrahydrofolate cyclo-ligase activity in vitro and does not complement the growth defect or the characteristic 5- formyltetrahydrofolate accumulation of a 5-FCL-deficient Escherichia coli strain. Instead, it may play a role in thiamin metabolism [PMID: 21538139].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
TIGRFAMs
PANTHER
PIRSF