Penicillin/GL-7-ACA/AHL/aculeacin-A acylase (IPR002692)

Short name: S45

Overlapping homologous superfamilies

Family relationships


This entry represents a number of acylases which all belong to MEROPS peptidase family S45 (clan PB).

Penicillin G acylase precursor and cephalosporin acylase precursor, more precisely termed glutaryl-7-aminocephalosporanic acid (GL-7-ACA) acylase, are self-cleaving proteins that spontaneously form the heterodimeric subunits of the mature acylases. They are not known to hydrolyse peptide bonds in other substrates, although they may have the capacity to do so.

This family also includes acyl-homoserine lactone (AHL) acylase PvdQ and QuiP, and aculeacin-A acylase, which has been shown to have penicillin acylase activity [PMID: 17586674].

GO terms

Biological Process

GO:0017000 antibiotic biosynthetic process

Molecular Function

GO:0016787 hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.