Nop domain (IPR002687)

Short name: Nop_dom

Overlapping homologous superfamilies

Domain relationships



The Nop domain is present in various pre-RNA processing ribonucleoproteins (RNP):

  • Eukaryotic Prp31, part of a tri-snRNP complex. It is involved in pre-mRNA splicing.
  • Eukaryotic Nucleolar proteins 56 and 58 (Nop56 and Nop58), components of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.
  • Archaeal Nop5, an homologue of Nop56/Nop58.

The Nop domain is a RNP binding module, exhibiting RNA and protein binding surfaces. It is oval-shaped and exclusively alpha-helical [PMID: 12598892, PMID: 17412961].

This entry represents the Nop domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles