Family

Glycosyl transferase, family 15 (IPR002685)

Short name: Glyco_trans_15

Family relationships

None.

Description

The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (EC:2.4.1.-) and related proteins into distinct sequence based families has been described [PMID: 9334165]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.

This entry represents a family of fungi mannosyl-transferases involved in N-linked and O-linked glycosylation of proteins. They belong to the glycosyltransferase family 15 (GT15). Some of the enzymes in this family have been shown to be involved in O- and N-linked glycan modifications in the Golgi [PMID: 9878809].

GO terms

Biological Process

GO:0006486 protein glycosylation

Molecular Function

GO:0000030 mannosyltransferase activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PIRSF
PANTHER