Reduced folate carrier (IPR002666)

Short name: Folate_carrier

Overlapping homologous superfamilies

Family relationships


This entry represents the reduced folate carrier family, including folate transporter 1 (SLC19A1), thiamine transporter 1 (SLC19A2) and thiamine transporter 2 (SLC19A3). Despite their protein sequence/structure similarity, they have different functions.

The transporter 1 (SLC19A1, also known as the reduced folate carrier protein, RFC) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy [PMID: 9161403], such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules [PMID: 9161403].

Thiamine transporter 1 (SLC19A2) and thiamine transporter 2 (SLC19A3) are high-affinity transporters for the intake of thiamine [PMID: 11731220]. They do not transport reduced or oxidized folates.

GO terms

Biological Process

GO:0051180 vitamin transport

Molecular Function

GO:0090482 vitamin transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.