Domain

Lysophospholipase, catalytic domain (IPR002642)

Short name: LysoPLipase_cat_dom

Domain relationships

Description

This family consists of lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 which also has a C2 domain IPR000008. Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolyzing all phospholipids extractable from yeast cells [PMID: 8027085]. Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids [PMID: 8051052], the aligned region corresponds the carboxy-terminal Ca2+-independent catalytic domain of the protein as discussed in [PMID: 8051052].

GO terms

Biological Process

GO:0009395 phospholipid catabolic process

Molecular Function

GO:0004620 phospholipase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
SMART
Pfam