tRNA-guanine(15) transglycosylase-like (IPR002616)

Short name: tRNA_ribo_trans-like

Family relationships


This is a family of queuine, archaeosine and general tRNA-ribosyltransferases EC:, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine at position 34 and with archaeosine at position 15 in archaeal tRNAs. In bacterial it catalyses the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified base queuine in the wobble position [PMID: 8654383, PMID: 8323579]. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H, and important tRNA and 7-aminomethyl-7deazaguanine binding residues [PMID: 8654383].

GO terms

Biological Process

GO:0008616 queuosine biosynthetic process
GO:0006400 tRNA modification

Molecular Function

GO:0008479 queuine tRNA-ribosyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.