Domain

CobQ/CobB/MinD/ParA nucleotide binding domain (IPR002586)

Short name: CobQ/CobB/MinD/ParA_Nub-bd_dom

Domain relationships

Description

This domain is found in various cobyrinic acid a,c-diamide synthases. These include CbiA (P29946) and CbiP (Q05597) from S. typhimurium [PMID: 8501034], and CobQ (Q52686) from R. capsulatus [PMID: 7635831]. These amidases catalyse amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria [PMID: 8501034].

The domain is also found in dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family [PMID: 2149583].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam