FtsK domain (IPR002543)

Short name: FtsK_dom

Overlapping homologous superfamilies

Domain relationships



The FtsK domain is a hydrophilic domain of about 200 residues, which is found in:

  • Bacterial cell division protein ftsK (known as sporulation protein SpoIIIE in Bacillus subtilis).
  • A set of conjugative plasmid- and conjugative transposon-encoded proteins, generally called Tra proteins. These proteins come from an extremly wide range of species, including Gram-positive and Gram-negative bacilli and cocci, Streptomyces species, Agrobacterium spp., and archaebacteria. In cases in which a function is known, the protein is required for intercellular DNA transfer.

The FtsK domain contains a highly conserved putative ATP-binding P-loop motif and is assumed to be cytoplasmic. It can be found in one to three copies and is thought to be involved in DNA translocation by coupling ATP hydrolysis to movement relative to the long axis of DNA [PMID: 7592387, PMID: 11433368, PMID: 11973144].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005524 ATP binding
GO:0003677 DNA binding
GO:0000166 nucleotide binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles