Multi antimicrobial extrusion protein (IPR002528)

Short name: MATE_fam

Family relationships


Characterised members of the Multi Antimicrobial Extrusion (MATE) family function as drug/sodium antiporters. These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibodies and drugs. MATE proteins are found in bacteria, archaea and eukaryotes. These proteins are predicted to have 12 alpha-helical transmembrane regions, some of the animal proteins may have an additional C-terminal helix [PMID: 12603313].

GO terms

Biological Process

GO:0006855 drug transmembrane transport
GO:0055085 transmembrane transport

Molecular Function

GO:0015297 antiporter activity
GO:0015238 drug transmembrane transporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.