Metalloprotease TldD/PmbA (IPR002510)

Short name: TldD/PmbA

Overlapping homologous superfamilies

Family relationships

  • Metalloprotease TldD/PmbA (IPR002510)


This entry represents a group of metalloproteases. The tertiary structure of the Escherichia coli TdlD/TdlE complex has been solved, and shows that the TdlD subunit is the active peptidase, binding a single zinc ion at an HEXXXH motif in which the glutamic acid is a substrate-binding residue and the two histidines are zinc ligands. The third zinc ligand is a cysteine, C-terminal to the HEXXXH motif. The TldE (also known as PmbA) by itself has no catalytic activity, does not bind zinc, and does not carry the HEXXXH motif [PMID: 28943336]. TldD and TldE were originally identified as regulators of DNA gyrase. Later, they are shown to be metalloproteases involved in CcdA degradation [PMID: 22950735, PMID: 12029038].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0008237 metallopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.