N-acetylmuramoyl-L-alanine amidase domain (IPR002502)

Short name: Amidase_domain

Overlapping homologous superfamilies

Domain relationships


Proteins containing this domain include zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC: This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala). The bacteriophage endolysins PLY118 and PLY500 cleave between L-Ala and D-Glu residues of Listeria cell-wall peptidoglycan and are therefore peptidases (MEROPS subfamily M15C) [PMID: 8577256]. The structure is known for the Bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding [PMID: 14506276, PMID: 12845326, PMID: 8171031, PMID: 15223330, PMID: 16556841, PMID: 18304640, PMID: 15140887, PMID: 16103125, PMID: 16428381].

GO terms

Biological Process

GO:0009253 peptidoglycan catabolic process

Molecular Function

GO:0008745 N-acetylmuramoyl-L-alanine amidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.