Family

Ferric-uptake regulator (IPR002481)

Short name: FUR

Family relationships

None.

Description

The Ferric uptake regulator (Fur) family includes metal ion uptake regulator proteins, which are responsible for controlling the intracellular concentration of iron in many bacteria. The Fur protein acts as an iron-responsive, DNA-binding repressor protein that binds to a 'Furbox' with the consensus sequence GATAATGATAATCATTATC in the promoter of iron-regulated genes. Under low-iron condition, the Fur protein is released from the promoter and transcription resumed [PMID: 8522528]. Furs can also control zinc homeostasis and is the subject of research on the pathogenesis of mycobacteria [PMID: 18452427, PMID: 12581348].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 sequence-specific DNA binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam