Palmitoyl protein thioesterase (IPR002472)

Short name: Palm_thioest

Overlapping homologous superfamilies

Family relationships


This entry represents the palmitoyl protein thioesterase family. Its members include palmitoyl-protein thioesterase 1 and lysosomal thioesterase 2 (PPT1 and PPT2). PPT1 is responsible for the removal of a palmitate group from its substrate proteins, which may include presynaptic proteins like SNAP-25, cysteine string protein (CSP), dynamin, and synaptotagmin [PMID: 24091420]. PPT2 removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA [PMID: 12855696]. PPT1 and -2 perform non-redundant roles in lysosomal thioester catabolism [PMID: 12855696].

Mutations in the PPT1 gene cause infantile-onset neuronal ceroid lipofuscinosis (INCL), which is a severe pediatric neurodegenerative disorder [PMID: 23747979].

This entry also includes uncharacterised proteins from fungi and plants.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0098599 palmitoyl hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.