Glucose transporter, type 1 (GLUT1) (IPR002439)

Short name: Glu_transpt_1

Overlapping homologous superfamilies

Family relationships


Facilitative sugar transport is mediated by members of the GLUT transporter family, which form an aqueous pore across the membrane through which sugars can move in a passive (i.e., energy-independent) manner. The GLUT family of glycosylated transmembrane proteins are predicted to span the membrane 12 times with both amino- and carboxyl-termini located in the cytosol. On the basis of sequence homology and structural similarity, three subclasses of sugar transporters have been defined: Class I (GLUTs 1-4) are glucose transporters; Class II (GLUTs 5, 7, 9 and 11) are fructose transporters; and Class III (GLUTs 6, 8, 10, 12 and HMIT1) are structurally atypical members of the GLUT family, which are poorly defined at present, indeed GLUT6 may only be a pseudo-gene [PMID: 2180146, PMID: 8366068, PMID: 3839598, PMID: 3170580, PMID: 9841639].

This entry represents GLUT1 (also called HepG2), which is the most ubiquitously distributed of the glucose transporter isoform. It is highly expressed in foetal tissues and adult brain microvessels. It is thought to provide glucose transport in various cells that form barriers between body tissues and the blood supply. It is found in epithelial and endothelial barrier cells, such as those that constitute the blood-brain barrier, and also in the placenta.

GO terms

Biological Process

GO:1904659 glucose transmembrane transport

Molecular Function

GO:0005355 glucose transmembrane transporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.