Natriuretic peptide, atrial type (IPR002407)
Short name: Natriuretic_peptide_atrial
Overlapping homologous superfamilies
- Natriuretic peptide (IPR000663)
- Natriuretic peptide, atrial type (IPR002407)
Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an important role in the control of cardiovascular homeostatis, and sodium and water balance in general [PMID: 1652921, PMID: 2536732]. There are different NPs that vary in length but share a common core. All are processed from a single precursor. A disulphide bond resident in the C-terminal section is required for full activity of atriopeptins. The family of NPs includes structurally-related peptides that elicit similar pharmacological spectra. Amongst these are brain natriuretic peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic peptide (VNP) [PMID: 1828035]; and Dendroaspis angusticeps (Eastern green mamba) natriuretic peptide (DNP) [PMID: 1352773]
Atrial natriuretic factor (ANF) is a potent vasoactive substance synthesized in mammalian atria and is thought to play a key role in cardiovascular homeostasis. It has a cGMP-stimulating activity.
- PR00711 (ANATPEPTIDE)