Family

Inhibin, alpha subunit (IPR002405)

Short name: Inhibin_asu

Family relationships

Description

Inhibins and activins are glycoproteins, secreted by the gonads, that belong to the transforming growth factor beta family [PMID: 2417121]. They participate in differentiation and growth of diverse cell types. Inhibin inhibits secretion of follicle-stimulating hormone by the pituitary [PMID: 3016724].

Inhibin has two isoforms, A and B, with the same alpha subunit but different beta subunits. Inhibin A is a dimer of alpha and beta A subunits, inhibin B is a dimer of alpha and beta B subunits.

Activin A is a dimer of beta A subunits, activin AB is a dimer of beta A and beta B chains.

Follistatin is bound to inhibin and activin and indirectly modulates the FSH release. In turn, FSH stimulates inhibin gene expression in the ovarian follicle [PMID: 7813465], probably mediated by cAMP [PMID: 2417121]. The serum levels of inhibin, activin, and follistatin are elevated in pregnant women and decrease after delivery [PMID: 9989858].

Genes coding for mouse activin beta C and beta E are closely linked and exhibit a liver-specific expression pattern in adult tissues.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS