Osteocalcin/matrix Gla protein (IPR002384)

Short name: Osteocalcin/MGP

Overlapping homologous superfamilies


Family relationships


Bone gamma-carboxyglutamic acid protein (BGP), also known as osteocalcin, and matrix gamma-carboxyglutamic acid protein (MGP) are the only vitamin K-dependent proteins that have been isolated from bone. MGP is a small protein found in bone, dentin and cartilage. It contains five gamma-carboxyglutamic acid (Gla) residues (formed by post-translational modification of glutamic acid by vitamin K-dependent carboxylase) and a single disulphide bond. BGP is a 49 residue protein found in bone. It contains three Gla residues and a single disulphide bond. There is little similarity between these vitamin K-dependent bone proteins and the blood coagulation proteins, though they are believed to have diverged from a common ancestor [PMID: 3317405].

GO terms

Biological Process

GO:0030500 regulation of bone mineralization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.