Conserved Site

Terpene synthase, conserved site (IPR002365)

Short name: Terpene_synthase_CS

Description

Several enzymes catalyse mechanistically related reactions which involve the highly complex cyclic rearrangement of squalene or its 2,3 oxide. Lanosterol synthase (EC:5.4.99.7) (oxidosqualene--lanosterol cyclase) catalyzes the cyclization of (S)-2,3-epoxysqualene to lanosterol, the initial precursor of cholesterol, steroid hormones and vitamin D in vertebrates and of ergosterol in fungi (gene ERG7). Cycloartenol synthase (EC:5.4.99.8) (2,3-epoxysqualene--cycloartenol cyclase), is a plant enzyme that catalyzes the cyclization of (S)-2,3-epoxysqualene to cycloartenol, and hopene synthase (EC:5.4.99) (squalene--hopene cyclase), is a bacterial enzyme that catalyzes the cyclization of squalene into hopene, a key step in hopanoid (triterpenoid) metabolism. These enzymes are evolutionary related [PMID: 7505443] proteins of about 70 to 85 kD. This highly conserved region is rich in aromatic residues and is located in the C-terminal section.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016866 intramolecular transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns