Interleukin-4 (IPR002354)

Short name: IL-4

Overlapping homologous superfamilies

Family relationships


Cytokines are protein messengers that carry information from cell to cell [PMID: 8151703]. Interleukin is one such molecule, and participates in several B-cell activation processes: e.g., it enhances production and secretion of IgG1 and IgE [PMID: 3083412]; it induces expression of class II major histocompatability complex (MHC) molecules on resting B-cells; and it regulates expression of the low affinity Fc receptor for IgE on lymphocytes and monocytes. Interleukin-4 (IL4), which this entry represents, has a compact, globular fold (similar to other cytokines), stabilised by 3 disulphide bonds [PMID: 1993171]. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist [PMID: 1400355]. The helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet [PMID: 1400355].

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0008083 growth factor activity
GO:0005136 interleukin-4 receptor binding

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.