Paraneoplastic encephalomyelitis antigen (IPR002343)

Short name: Hud_Sxl_RNA

Overlapping homologous superfamilies


Family relationships


Many eukaryotic proteins that are either known or thought to bind single-stranded RNA contain one or more copies of a putative RNA-binding domain of about 90 amino acids [PMID: 2470643, PMID: 3072706]. This region has been found in, for example, heterogeneous nuclear ribonucleoproteins, small nuclear ribonucleoproteins, pre-RNA and mRNA associated proteins, Drosophila sex determination and elav proteins, human paraneoplastic encephalomyelitis antigen HuD, and many others. The structure of an RNA-binding domain of Drosophila Sex-lethal (Sxl) protein has been determined using multi-dimensional hetero-nuclear NMR [PMID: 7524663]. Sxl contains two RNP consensus-type RNA-binding domains (RBDs) - the determined structure represents the second of these (RBD-2) [PMID: 7524663]. The calculated intermediate-resolution family of structures exhibits the beta-alpha-beta/beta-alpha-beta tertiary fold found in other RBD-containing proteins [PMID: 7524663].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.