Hepatic lipase (IPR002333)

Short name: Lipase_hep

Overlapping homologous superfamilies

Family relationships


Triglyceride lipases (EC: are lipolytic enzymes that hydrolyse ester linkages of triglycerides [PMID: 3147715]. Lipases are widely distributed in animals, plants and prokaryotes. At least three tissue-specific isozymes exist in higher vertebrates: pancreatic, hepatic and gastric/lingual. These lipases are closely related to each other and to lipoprotein lipase (EC:, which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL) [PMID: 2917565]. Familial human hepatic lipase deficiency is a rare recessive disorder that results from mutation in position 405 of the mature protein. The disease is characterised by premature atherosclerosis and abnormal circulating lipoproteins [PMID: 1301939]. The structure of the human hepatic triglyceride lipase gene has been determined [PMID: 2605236]. The hepatic lipase gene spans ~60 kb, and contains 8 introns and 9 exons: exon 1 encodes the signal peptide; exon 4, a region that binds to the lipoprotein substrate; exon 5, an evolutionarily highly-conserved region of potential catalytic function; and exons 6 and 9 encode sequences rich in basic amino acids, thought to be important in anchoring the enzyme to the endothelial surface by interacting with acidic domains of surface glycosaminoglycans [PMID: 2605236]. The human lipoprotein lipase gene has an identical exon-intron organisation, with analogous structural domains, supporting the common evolutionary origin of these two lipolytic enzymes [PMID: 3823907].

GO terms

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

GO:0004806 triglyceride lipase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.