Amino acid/polyamine transporter I (IPR002293)

Short name: AA/rel_permease1

Overlapping homologous superfamilies


Family relationships


Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [PMID: 3146645, PMID: 2687114, PMID: 8382989]. These proteins include several yeast specific and general amino acid permeases; Emericella nidulans (Aspergillus nidulans) proline transport protein (gene prnB); Trichoderma harzianum amino acid permease INDA1; Salmonella typhimurium L-asparagine permease (gene ansP); and several Escherichia coli and other bacterial permeases and transport proteins. These proteins seem to contain up to 12 transmembrane segments. This entry consists of members of the amino acid-polyamine-organocation (APC) superfamily [PMID: 10931886].

Also included in this entry is the methylthioribose transporter mtrA from Bacillus subtilis, which transports methylthioribose into the cell [PMID: 29280348].

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0022857 transmembrane transporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.