MAGE homology domain (IPR002190)

Short name: MHD_dom

Domain relationships



The first mammalian members of the MAGE (melanoma-associated antigen) gene family were originally described as completely silent in normal adult tissues, with the exception of male germ cells and, for some of them, placenta. By contrast, these genes were expressed in various kinds of tumors. However, other members of the family were recently found to be expressed in normal cells, indicating that the family is larger and more disparate than initially expected. MAGE-like genes have also been identified in non-mammalian species, including Drosophila melanogaster (Fruit fly) and Danio rerio (Zebrafish). Although no MAGE homologous sequences have been identified in Caenorhabditis elegans, Saccharomyces cerevisiae (Baker's yeast) or Schizosaccharomyces pombe (Fission yeast), MAGE sequences have been found in several vegetal species, including Arabidopsis thaliana (Mouse-ear cress) [PMID: 11454705].

The only region of homology shared by all of the members of the family is a stretch of about 200 amino acids which has been named the MAGE homology domain. The MAGE homology domain is usually located close to the C-terminal, although it can also be found in a more central position in some proteins. The MAGE homology domain is generally present as a single copy but it is duplicated in some proteins. It has been proposed that the MAGE homology domain of MAGE-D proteins might interact with p75 neurotrophin or related receptors [PMID: 11454705].

Proteins known to contain a MAGE domain are listed below:

  • Human MAGE-A, -B and -C proteins. MAGE-A, -B and -C genes are silent in all normal tissues with the exception of testis.
  • Human MAGE-D to -L proteins. MAGE-D to -L genes are expressed in normal adult tissues.
  • Mouse Mage-a and -b proteins.
  • Mouse Mage-d, -e, -g, -h, -k and -l.
  • Mammalian Necdin. The human Necdin gene is a candidate for the Prader-Willi syndrome.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles