Active Site

Lipase, GDXG, active site (IPR002168)

Short name: Lipase_GDXG_AS


These enzymes contain a Ser-centred consensus sequence and a conserved His-Gly dipeptide found in most lipase amino-terminal domains. These sequences are involved in the lipase active site conformation since substitution of the conserved Ser or His residues by Ala and Gln, respectively, results in the loss of both lipase and esterase activities [PMID: 1907455].

GO terms

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0016787 hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns