Graves disease carrier protein (IPR002167)

Short name: Graves_DC

Overlapping homologous superfamilies

Family relationships


A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane [PMID: 2158156, PMID: 8325039, PMID: 8140286, PMID: 8487299]. Such proteins include: ADP,ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others.

Graves disease carrier protein (GDC) is a protein of as yet uncharacterised function that belongs to the mitochondrial metabolite carrier family (which includes the ADP/ATP translocator, the phosphate carrier and the hydrogen ion uncoupling protein) [PMID: 8325039, PMID: 2575220]. The protein is recognised by IgG from patients with active Graves disease.

GDC is an integral membrane protein thought to reside in the inner mitochondrial membrane. The predicted amino acid sequence of 348 residues comprises three similar domains.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005743 mitochondrial inner membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.