Family

Glutamine amidotransferase subunit PdxT (IPR002161)

Short name: Glutamine_amidoTferase_suPdxT

Family relationships

None.

Description

Members of this family are involved in the pyridoxine biosynthetic pathway [PMID: 8955308, PMID: 9791124]. The regulation of cellular growth and proliferation in response to environmental cues is critical for development and the maintenance of viability in all organisms. In unicellular organisms, such as the budding yeast Saccharomyces cerevisiae (Baker's yeast), growth and proliferation are regulated by nutrient availability.

Pyridoxal 5'-phosphate (PLP) is synthesized by the PdxA/PdxJ pathway in some species (mostly within the gamma subdivision of the proteobacteria) and by the Pdx1/Pdx2 pathway in most other organisms. This family describes PdxT, the glutaminase subunit of the PLP synthase. It is involved in the hydrolysis of glutamine to glutamate and ammonia, channeling an ammonia molecule to PdxS.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
Pfam
PROSITE profiles
TIGRFAMs
HAMAP