Ribokinase (IPR002139)

Short name: Ribokinase

Family relationships


Ribokinases participate in the first step of ribose metabolism, and are members of the superfamily of carbohydrate kinases. Ribokinases phosphorylate ribose to ribose-5-phosphate in the presence of ATP and magnesium [PMID: 9385653]:

ATP + D-Ribose = ADP + D-Ribose-5-Phosphate

The phosphorylated sugar may then enter the pentose phosphate pathway [PMID: 8577746].

There are indications that the phosphorylated sugar may also be used in the synthesis of amino acids (histidine and tryptophan). Further, links to mammalian adenosine kinase have been identified, through sequence similarity, suggesting possible homology [PMID: 8577746, PMID: 8917457].

GO terms

Biological Process

GO:0006014 D-ribose metabolic process

Molecular Function

GO:0004747 ribokinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.