Ribokinase/fructokinase (IPR002139)

Short name: Ribo/fructo_kinase

Overlapping homologous superfamilies

Family relationships


Ribokinases participate in the first step of ribose metabolism, and are members of the superfamily of carbohydrate kinases. Ribokinases phosphorylate ribose to ribose-5-phosphate in the presence of ATP and magnesium [PMID: 9385653]:

ATP + D-Ribose = ADP + D-Ribose-5-Phosphate

The phosphorylated sugar may then enter the pentose phosphate pathway [PMID: 8577746]. There are indications that the phosphorylated sugar may also be used in the synthesis of amino acids (histidine and tryptophan). Further, links to mammalian adenosine kinase have been identified, through sequence similarity, suggesting possible homology [PMID: 8577746, PMID: 8917457].

This family also includes fructokinases [PMID: 8382990]. Fructokinase may be involved in a sugar-sensing pathway in plants [PMID: 11120475].

This family also includes cytidine kinase from Thermococcus kodakarensis and MJ0406 (Q57849) from Methanocaldococcus jannaschii. MJ0406 was previously annotated as a 6-phosphofructokinases (PFK), but has since been characterised as a functional nucleoside kinase [PMID: 17021658].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016301 kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.