Domain

NADH:ubiquinone/plastoquinone oxidoreductase, chloroplast chain 5, C-terminal (IPR002128)

Short name: NADH_UbQ_OxRdtase_chlpt_su5_C

Domain relationships

None.

Description

NADH:ubiquinone oxidoreductase (complex I) (EC:1.6.5.3) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [PMID: 1470679]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [PMID: 10940377], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [PMID: 18394423].

This domain represents a C-terminal extension of NADH-Ubiquinone/plastoquinone (complex I) chains (see IPR001750). Chain 5 is a component of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane [PMID: 1470679].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam