Domain

Phospholipid/glycerol acyltransferase (IPR002123)

Short name: Plipid/glycerol_acylTrfase

Overlapping homologous superfamilies

None.

Domain relationships

Description

This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function [PMID: 9259571]. This domain is found in tafazzins, defects in which are the cause of Barth syndrome; a severe inherited disorder which is often fatal in childhood and is characterised by cardiac and skeletal abnormalities. Phospholipid/glycerol acyltransferase is not found in the viruses or the archaea and is under represented in the bacteria. Bacterial glycerol-phosphate acyltransferases are involved in membrane biogenesis since they use fatty acid chains to form the first membrane phospholipids [PMID: 18369234].

GO terms

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0016746 transferase activity, transferring acyl groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam