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Overview
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Pathways & interactions
Phospholipid/glycerol acyltransferase (IPR002123)
Short name: Plipid/glycerol_acylTrfase
Overlapping homologous superfamilies
None.
Domain relationships
- Phospholipid/glycerol acyltransferase (IPR002123)
- 1-acyl-sn-glycerol-3-phosphate acyltransferase (IPR004552)
Description
This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function [PMID: 9259571]. This domain is found in tafazzins, defects in which are the cause of Barth syndrome; a severe inherited disorder which is often fatal in childhood and is characterised by cardiac and skeletal abnormalities. Phospholipid/glycerol acyltransferase is not found in the viruses or the archaea and is under represented in the bacteria. Bacterial glycerol-phosphate acyltransferases are involved in membrane biogenesis since they use fatty acid chains to form the first membrane phospholipids [PMID: 18369234].
GO terms
Biological Process
GO:0008152 metabolic process
Molecular Function
GO:0016746 transferase activity, transferring acyl groups
Cellular Component
No terms assigned in this category.