Thyrotropin-releasing hormone receptor (IPR002120)

Short name: TRH_rcpt_1

Overlapping homologous superfamilies


Family relationships


Thyrotropin-releasing hormone, also known as thyroliberin (TRH) stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary [PMID: 4982117, PMID: 4985794]. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin [PMID: 8147889]. In the CNS, TRH stimulates a number of behavioural and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens [PMID: 2423357]. TRH initiates all of these effects by interacting with receptors that belong to a class of G protein-coupled receptors, rhodopsin-type (GPCRA) [PMID: 12683933].

There are two thyrotropin-releasing hormone receptors, thyrotropin-releasing hormone receptor (TRH1) which has been found in a number of species including rat, mouse and human [PMID: 2175902, PMID: 1377915, PMID: 8395824] and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents [PMID: 9822707, PMID: 11181534]. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain [PMID: 18984166, PMID: 8387653, PMID: 10628757]. The receptors activate phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, probably of the Gq/G11 class [PMID: 1333052, PMID: 1334076].

This entry represents the thyrotrophin-releasing hormone receptor.

GO terms

Biological Process

GO:0007186 G protein-coupled receptor signaling pathway

Molecular Function

GO:0004997 thyrotropin-releasing hormone receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.