Pathways & interactions
Adenine nucleotide translocator 1 (IPR002113)
Short name: Aden_trnslctor
Overlapping homologous superfamilies
- Mitochondrial carrier domain superfamily (IPR023395)
- Mitochondrial carrier protein (IPR002067)
- Adenine nucleotide translocator 1 (IPR002113)
A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane [PMID: 2158156, PMID: 8325039, PMID: 8140286, PMID: 8487299]. Such proteins include: ADP,ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others.
Sequence analysis of selected members of the carrier protein family has suggested the presence of six transmembrane (TM) domains, with varying degrees of sequence conservation and hydrophilicity [PMID: 8325039]. The TM regions, and adjacent hydrophilic loops, are more highly conserved than other regions of the proteins [PMID: 8325039]. All members of the family appear to consist of a tripartite structure, each of the repeated segments being ~100 residues in length [PMID: 8325039]. Each repeat contains two TM domains, the first being more hydrophobic, with conserved glycyl and prolyl residues. Five of the six TM domains are followed by the conserved sequence (D/E)-Hy(K/R), where - denotes any residue and Hy is a hydrophobic position [PMID: 8325039].
Mitochondrial ADP/ATP translocase, an abundant component of the inner membrane, carries ATP from the matrix into the inter-membrane space and transports ADP back [PMID: 2541251]. The protein is an integral membrane protein that functions as a homodimer.
- PR00927 (ADPTRNSLCASE)