DNA mismatch repair protein family, N-terminal (IPR002099)

Short name: DNA_mismatch_repair_N

Overlapping homologous superfamilies

Domain relationships



This entry represents the N-terminal domain of DNA mismatch repair proteins, such as MutL. Bacterial MutL proteins are homodimers, while their eukaryotic homologues form heterodimers consisting of the MutL homologue Mlh1 and either Pms1, Pms2 or Mlh3 [PMID: 26436461, PMID: 10570173]. MutL proteins and their homologues share sequence homology at their N termini over the first 300-400 residues; the C termini are less well conserved, they constitute the main dimerization domain and are required for interaction between MutL and UvrD helicase [PMID: 10946232]. The activity of the protein is modulated by the ATP-dependent dimerization of the N-terminal domain [PMID: 16024043].

The dimeric MutL protein has a key function in communicating mismatch recognition by MutS to downstream repair processes. Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex [PMID: 14527292].

GO terms

Biological Process

GO:0006298 mismatch repair

Molecular Function

GO:0005524 ATP binding
GO:0030983 mismatched DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.