Seminal vesicle protein I (IPR002098)

Short name: SVP_I


Seminal vesicle protein I (SVP-1) is one of the four major secretory proteins secreted by Cavia porcellus (Guinea pig) seminal vesicle epithelium. It is a clotting protein that serves as the substrate in the formation of the copulatory plug. Covalent clotting of this protein is catalyzed by a transglutaminase and involves the formation of gamma-glutamyl-epsilon-lysine crosslinks. SVP-1 sequence contains eight repeats of a twenty four amino acid residue domain. There are seven invariant residues in these repeats, three of them (two lysines and one glutamine) probably participate in the cross-links [PMID: 3477802].

These repeats are also present twice in the N-terminal region of the precursor of human skin elafin, an inhibitor of elastase as well as in the precursor of Sus scrofa (Pig) sodium/potassium atpase inhibitor SPAI-2.

GO terms

Biological Process

GO:0007620 copulation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns