ELO family (IPR002076)

Short name: ELO_fam

Overlapping homologous superfamilies


Family relationships


The ELO family consist of eukaryotic integral membrane proteins involved in fatty acid elongation. This family consist of:

  • Mammalian proteins ELOVL1 to ELOVL4 [PMID: 10791983]. These proteins all seem to be involved in the synthesis of very long chain fatty acids.
  • Yeast ELO1, ELO2 and ELO3 [PMID: 9211877]. They seem to be components of membrane-bound fatty acid elongation systems.
  • Caenorhabditis elegans hypothetical protein C40H1.4.
  • Caenorhabditis elegans hypothetical protein D2024.3.

This group of eukaryotic integral membrane proteins are evolutionary related, but exact function has not yet clearly been established. The proteins have from 290 to 435 amino acid residues. Structurally, they seem to be formed of three sections: a N-terminal region with two transmembrane domains, a central hydrophilic loop and a C-terminal region that contains from one to three transmembrane domains. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis [PMID: 8027068]. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 (P40319) affects plasma membrane H+-ATPase activity, and may act on a glucose-signalling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1 [PMID: 7768822].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.