Nuclear transport factor 2 (IPR002075)

Short name: NTF2

Domain relationships


Nuclear transport factor 2 (NTF2) is a homodimer which stimulates efficient nuclear import of a cargo protein. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. NTF2 folds into a cone with a deep hydrophobic cavity, the opening of which is surrounded by several negatively charged residues. RanGDP binds to NTF2 by inserting a conserved phenylalanine residue into the hydrophobic pocket of NTF2 and making electrostatic interactions with the conserved negatively charged residues that surround the cavity [PMID: 9533885].

This entry represent the main structural domain of NTF2 and related domains which are found in other nuclear import proteins.

GO terms

Biological Process

GO:0006810 transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005622 intracellular

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.