Active Site

Thermonuclease active site (IPR002071)

Short name: Thermonucl_AS


Staphylococcus aureus secretes a thermostable nuclease (EC:, known as thermonuclease (TNase), which is a calcium-dependent enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond yielding 3'-mononucleotides and dinucleotides [PMID: 1896431]. This signature contains the three residues, two arginines and a glutamate, that form the active site. The sequence of the TNase of S. aureus is evolutionary related [PMID: 8045422] to other TNase's of other Staphylococcus spp as well as to several other proteins.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004518 nuclease activity
GO:0003676 nucleic acid binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns