Family

Interferon gamma (IPR002069)

Short name: Interferon_gamma

Family relationships

None.

Description

Interferon gamma (IFN-gamma) is produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma shows antiviral activity and has important immunoregulatory functions. It is a potent activator of microphages and had antiproliferative effects on transformed cells. It can potentiate the antiviral and antitumor effects of the type I interferons.

The crystal structures of a number IFN-gamma proteins have been solved, including bovine interferon-gamma at 2.0-A [PMID: 10666622] and human IFN-gamma at 2.9-A [PMID: 10860730].

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0005133 interferon-gamma receptor binding

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
ProDom
Pfam
PIRSF
PANTHER