Mitochondrial carrier protein (IPR002067)

Short name: Mit_carrier

Overlapping homologous superfamilies

Family relationships


A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane [PMID: 2158156, PMID: 8325039, PMID: 8140286, PMID: 8487299]. Such proteins include: ADP/ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. This family also includes peroxisomal proteins like PMP34 [PMID: 11121399].

Sequence analysis of selected members of the carrier protein family has suggested the presence of six transmembrane (TM) domains, with varying degrees of sequence conservation and hydrophilicity [PMID: 8325039]. The TM regions, and adjacent hydrophilic loops, are more highly conserved than other regions of the proteins [PMID: 8325039]. All members of the family appear to consist of a tripartite structure, each of the repeated segments being about 100 residues in length [PMID: 8325039]. Each repeat contains two TM domains, the first being more hydrophobic, with conserved glycyl and prolyl residues. Five of the six TM domains are followed by the conserved sequence (D/E)-Hy(K/R), where - denotes any residue and Hy is a hydrophobic position [PMID: 8325039].

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.