Protein import receptor MAS20 (IPR002056)

Short name: MAS20

Overlapping homologous superfamilies

Family relationships


Virtually all mitochondrial precursors are imported via the same mechanism [PMID: 7709435]: precursors first bind to receptors on the mitochondrial surface, then insert into the translocation channel in the outer membrane. Many outer-membrane proteins participate in the early stages of import, four of which (MAS20, MAS22, MAS37 and MAS70) are components of the receptor. MAS20, which forms a subcomplex with MAS22, seems to interact with most or all mitochondrial precursors, suggesting that the protein binds directly to mitochondrial targeting sequences. The MAS37 and MAS70 components also form a subcomplex, the two subcomplexes possibly binding via their trans- membrane (TM) regions - the TM region of MAS70 promotes oligomerisation of attatched protein domains and shares sequence similarity with the TM region of MAS20 [PMID: 8163528].

MAS20 is also known as TOM20.

GO terms

Biological Process

GO:0006886 intracellular protein transport
GO:0006605 protein targeting

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005742 mitochondrial outer membrane translocase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.