Glycoside hydrolase, family 25 (IPR002053)

Short name: Glyco_hydro_25

Overlapping homologous superfamilies

Family relationships


O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 25 GH25 comprises enzymes with only one known activity; lysozyme (EC:

It has been shown [PMID: 1916274, PMID: 1747104] that a number of cell-wall lytic enzymes are evolutionary related and can be classified into a single family. Two residues, an aspartate and a glutamate, have been shown [PMID: 567645] to be important for the catalytic activity of the Charalopsis enzyme. These residues as well as some others in their vicinity are conserved in all proteins from this family.

GO terms

Biological Process

GO:0016998 cell wall macromolecule catabolic process
GO:0009253 peptidoglycan catabolic process

Molecular Function

GO:0003796 lysozyme activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.