Conserved Site

Alpha-isopropylmalate/homocitrate synthase, conserved site (IPR002034)

Short name: AIPM/Hcit_synth_CS


A number of enzymes have been shown to be functionally as well as evolutionary related [PMID: 2022611]. The nifV and leuA genes encode homocitrate synthase and alpha-isopropylmalate synthase, respectively The N-terminal parts of NifV and LeuA from bacteria are highly similar to each other [PMID: 9139910]. Homocitrate synthase (EC: (gene nifV) is involved in the biosynthesis of the iron-molybdenum cofactor of nitrogenase and catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate into homocitrate. Alpha-isopropylmalate synthase (EC: catalyses the first step in the biosynthesis of leucine, the condensation ofacetyl-CoA and alpha- ketoisovalerate to form 2-isopropylmalate synthase.

GO terms

Biological Process

GO:0019752 carboxylic acid metabolic process

Molecular Function

GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns