Pathways & interactions
Mitochondrial brown fat uncoupling protein (IPR002030)
Short name: Mit_uncoupling
- Mitochondrial brown fat uncoupling protein (IPR002030)
- Brain mitochondrial carrier protein 1 (IPR032933)
A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane [PMID: 2158156, PMID: 8140286, PMID: 8487299, PMID: 8206158, PMID: 8291088]. Such proteins include: ADP,ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mito- chondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others.
The brown fat uncoupling protein (UCP) dissipates oxidative energy into heat by transporting protons from the cytosol into the mitochondrial matrix [PMID: 2380264]. UCP functions as a dimer, forming a proton channel that leads to uncoupling of oxidative phosphorylation by dissipation of the electrochemical potential across the inner membrane.
The protein has a tripartite structure, with 3 similar ~100 residue domains. The domains exhibit striking conservation of several residues, especially of glycine and proline, which may constitute structurally strategic positions [PMID: 3000775]. The protein is thought to contain 6 transmembrane helices [PMID: 3410843]. These characteristics are shared by the ADP/ATP carrier protein, which is a member of the mitochondrial carrier family.
- PR00784 (MTUNCOUPLING)