NADH-quinone oxidoreductase subunit E-like (IPR002023)

Short name: NuoE-like

Overlapping homologous superfamilies

Family relationships


Respiratory-chain NADH dehydrogenase (EC: [PMID: 2029890] (also known as complex I or NADH-ubiquinone oxidoreductase) is an oligomeric enzymatic complex located in the inner mitochondrial membrane which also seems to exist in the chloroplast and in cyanobacteria (as a NADH-plastoquinone oxidoreductase). Among the 25 to 30 polypeptide subunits of this bioenergetic enzyme complex there is one with a molecular weight of 24 Kd (in mammals), which is a component of the iron-sulfur (IP) fragment of the enzyme. It seems to bind a 2Fe-2S iron-sulfur cluster. The 24 Kd subunit is nuclear encoded, as a precursor form with a transit peptide in mammals, and in Neurospora crassa. The 24 Kd subunit is highly similar to [PMID: 1445936, PMID: 7690854]: Subunit E of Escherichia coli NADH-ubiquinone oxidoreductase (gene nuoE). Subunit NQO2 of Paracoccus denitrificans NADH-ubiquinone oxidoreductase.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns