Conserved Site

Osteonectin-like, conserved site (IPR001999)

Short name: Osteonectin_CS

Description

The osteonectin like domain, of unknown function, is found in extracellular proteins strongly expressed in tissues undergoing morphogenesis. It is a 240 amino acids domain, highly conserved, localized in the C-terminal part of the protein [PMID: 8119487].

This domain has a N-terminal section of about 90 residues that contains 11 conserved cysteines, a central section that is probably in an alpha-helical conformation, and a C-terminal section that contains two EF-hand type calcium-binding regions [PMID: 8548457] and three conserved cysteines. This topology is schematically represented below.

                                                                    +----+
                                                                     |    |
 xCxCxCxxCCxCxxxCxxCxCxxxxxCxCxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx(Ca)xCxxC(Ca)Cxx

C: conserved cysteines involved in disulphide bonds. Ca: EF-hand region see(IPR002048).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns