Family

Sodium:dicarboxylate symporter (IPR001991)

Short name: Na-dicarboxylate_symporter

Family relationships

Description

It has been shown [PMID: 8031825] that integral membrane proteins that mediate the uptake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. One of these families [PMID: 1279699] is known as the sodium:dicarboxylate symporter family (SDF).

Such re-uptake of neurotransmitters from the synapses, is thought to be an important mechanism for terminating their action, by removing these chemicals from the synaptic cleft, and transporting them into presynaptic nerve terminals, and surrounding neuroglia. this removal is also believed to prevent them accumulating to the point of reaching neurotoxic [PMID: 1448170, PMID: 1280334].

The structure of these transporter proteins has been variously reported to contain from 8 to 10 transmembrane (TM) regions, although 10 now seems to be the accepted value.

Members of the family include: several mammalian excitatory amino acid transporters, and a number of bacterial transporters. They vary with regars to their dependence on transport of sodium, and other ions.

GO terms

Biological Process

GO:0006835 dicarboxylic acid transport

Molecular Function

GO:0017153 sodium:dicarboxylate symporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PRINTS
GENE3D
PANTHER
SUPERFAMILY